Lower East Side
It may be a little rough around the edges but its diverse cultural heritage and a recent injection of artistic influence have made the LES achingly cool.
With the rest of the city watching its every move, it's a trend setter in the truest sense and nowhere is this more apparent than in its alluring bars and nightclubs.
LES does more than just bars and nightclubs though, and where this place really sets itself apart is with its live music nights and burlesque shows. You may want more than one night here.